The Commission on Chicago Landmarks interfaces with the Committee on Zoning, Landmarks and Building Standards primarily on matters related to landmark designations and permits for landmark properties. After the Landmarks Commission recommends a building, structure, or district for landmark status, the matter goes to the Zoning Committee for consideration before proceeding to the full City Council for final approval.

Additionally, certain zoning changes that affect landmark properties or districts must be reviewed by both bodies, ensuring that preservation concerns are addressed within the broader zoning process.